The article analyzes the results of laboratory blood tests obtained from patients on the day of admission to the emergency room and calculates various leukocyte indices in patients with burn disease. The study was conducted based on the case histories of the Republican Clinical Hospital of the Ministry of Health of Chuvashia in the period 2024–2025. The study was aimed at identifying the informativeness of leukocyte indices in relation to predicting the severity of burn disease. Some leukocyte indices are sufficiently informative in predicting the severity of this disease.