The problem of the spread of natural infections transmitted by ixodid ticks remains relevant for Russian healthcare, affecting both the medical sphere and the social life of society. The aim of the study is to conduct an epidemiological analysis of tick-borne encephalitis (TBE) and Lyme borreliosis (LB) in the Republic of Tatarstan from 2020 to 2024. The research focuses on identifying trends in morbidity rates and evaluating preventive measures' effectiveness. Materials and methods: Data were collected from official reports “On the State of Sanitary-Epidemiological Well-being of the Population of the Republic of Tatarstan” for 2020–2024 and publication of scientific journals. A retrospective analysis was employed to assess changes in TBE and LB morbidity over this period. Results: Local cases of TBE decreased gradually except for 2023 and 2024 when the first indigenous infections occurred within Tatarstan's territory. In contrast, LB incidence remained relatively stable with minor fluctuations across years. Annual increases in patient visits due to tick bites were observed; however, detection rate of TBE virus in tested samples remained consistently low. Conclusion: Epidemiological situation in Tatarstan demonstrates relative stability and a low frequency of dangerous tick-borne infections transmission. Nevertheless, further efforts are needed to improve prevention strategies, raise public awareness, and enhance healthcare services quality. Keywords: Tick-borne Encephalitis, Lyme Borreliosis, Vaccination Efficiency, Vaccination Coverage, Population Morbidity.